Molecular changes associated with the transmission of avian influenza a H5N1 and H9N2 viruses to humans
Identifieur interne : 001772 ( Main/Exploration ); précédent : 001771; suivant : 001773Molecular changes associated with the transmission of avian influenza a H5N1 and H9N2 viruses to humans
Auteurs : M. Shaw [Géorgie (pays), États-Unis] ; L. Cooper [Géorgie (pays)] ; X. Xu [Géorgie (pays)] ; W. Thompson [Géorgie (pays)] ; S. Krauss [États-Unis] ; Y. Guan [République populaire de Chine] ; N. Zhou [États-Unis] ; A. Klimov [Géorgie (pays)] ; N. Cox [Géorgie (pays)] ; R. Webster [États-Unis] ; W. Lim [République populaire de Chine] ; K. Shortridge [République populaire de Chine] ; K. Subbarao [Géorgie (pays)]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2002-01.
Abstract
In order to identify molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans, the internal genes from these viruses were compared to sequences from other avian and human influenza A isolates. Phylogenetically, each of the internal genes of all sixteen of the human H5N1 and both of the H9N2 isolates were closely related to one another and fell into a distinct clade separate from clades formed by the same genes of other avian and human viruses. All six internal genes were most closely related to those of avian isolates circulating in Asia, indicating that reassortment with human strains had not occurred for any of these 18 isolates. Amino acids previously identified as host‐specific residues were predominantly avian in the human isolates although most of the proteins also contained residues observed previously only in sequences of human influenza viruses. For the majority of the nonglycoprotein genes, three distinct subgroups could be distinguished on bootstrap analyses of the nucleotide sequences, suggesting multiple introductions of avian virus strains capable of infecting humans. The shared nonglycoprotein gene constellations of the human H5N1 and H9N2 isolates and their detection in avian isolates only since 1997 when the first human infections were detected suggest that this particular gene combination may confer the ability to infect humans and cause disease. J. Med. Virol. 66:107–114, 2002. Published 2002 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.2118
Affiliations:
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Cooper</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Xu, X" sort="Xu, X" uniqKey="Xu X" first="X." last="Xu">X. Xu</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Thompson, W" sort="Thompson, W" uniqKey="Thompson W" first="W." last="Thompson">W. Thompson</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Krauss, S" sort="Krauss, S" uniqKey="Krauss S" first="S." last="Krauss">S. Krauss</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, N" sort="Zhou, N" uniqKey="Zhou N" first="N." last="Zhou">N. Zhou</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A." last="Klimov">A. Klimov</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Cox, N" sort="Cox, N" uniqKey="Cox N" first="N." last="Cox">N. Cox</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Webster, R" sort="Webster, R" uniqKey="Webster R" first="R." last="Webster">R. Webster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Lim, W" sort="Lim, W" uniqKey="Lim W" first="W." last="Lim">W. Lim</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Government Virus Unit, Queen Mary Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Shortridge, K" sort="Shortridge, K" uniqKey="Shortridge K" first="K." last="Shortridge">K. Shortridge</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Subbarao, K" sort="Subbarao, K" uniqKey="Subbarao K" first="K." last="Subbarao">K. Subbarao</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">66</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="114">114</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-01">2002-01</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to identify molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses to humans, the internal genes from these viruses were compared to sequences from other avian and human influenza A isolates. Phylogenetically, each of the internal genes of all sixteen of the human H5N1 and both of the H9N2 isolates were closely related to one another and fell into a distinct clade separate from clades formed by the same genes of other avian and human viruses. All six internal genes were most closely related to those of avian isolates circulating in Asia, indicating that reassortment with human strains had not occurred for any of these 18 isolates. Amino acids previously identified as host‐specific residues were predominantly avian in the human isolates although most of the proteins also contained residues observed previously only in sequences of human influenza viruses. For the majority of the nonglycoprotein genes, three distinct subgroups could be distinguished on bootstrap analyses of the nucleotide sequences, suggesting multiple introductions of avian virus strains capable of infecting humans. The shared nonglycoprotein gene constellations of the human H5N1 and H9N2 isolates and their detection in avian isolates only since 1997 when the first human infections were detected suggest that this particular gene combination may confer the ability to infect humans and cause disease. J. Med. Virol. 66:107–114, 2002. Published 2002 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Tennessee</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Shaw, M" sort="Shaw, M" uniqKey="Shaw M" first="M." last="Shaw">M. Shaw</name></noRegion><name sortKey="Cooper, L" sort="Cooper, L" uniqKey="Cooper L" first="L." last="Cooper">L. Cooper</name><name sortKey="Cox, N" sort="Cox, N" uniqKey="Cox N" first="N." last="Cox">N. Cox</name><name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A." last="Klimov">A. Klimov</name><name sortKey="Subbarao, K" sort="Subbarao, K" uniqKey="Subbarao K" first="K." last="Subbarao">K. Subbarao</name><name sortKey="Thompson, W" sort="Thompson, W" uniqKey="Thompson W" first="W." last="Thompson">W. Thompson</name><name sortKey="Xu, X" sort="Xu, X" uniqKey="Xu X" first="X." last="Xu">X. Xu</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Shaw, M" sort="Shaw, M" uniqKey="Shaw M" first="M." last="Shaw">M. Shaw</name></region><name sortKey="Krauss, S" sort="Krauss, S" uniqKey="Krauss S" first="S." last="Krauss">S. Krauss</name><name sortKey="Webster, R" sort="Webster, R" uniqKey="Webster R" first="R." last="Webster">R. Webster</name><name sortKey="Zhou, N" sort="Zhou, N" uniqKey="Zhou N" first="N." last="Zhou">N. Zhou</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name></noRegion><name sortKey="Lim, W" sort="Lim, W" uniqKey="Lim W" first="W." last="Lim">W. Lim</name><name sortKey="Shortridge, K" sort="Shortridge, K" uniqKey="Shortridge K" first="K." last="Shortridge">K. Shortridge</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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